The flu causes up to 650,000 deaths worldwide each year. According to CDC USA in 2019-2020 the flu caused 86,000 deaths. Patients with chronic kidney disease (CKD) are at high risk for serious complications and adverse effects of influenza infection. A feature of this year is the possibility of combining influenza with COVID-19, which can significantly complicate treatment and worsen the prognosis of patients with CKD. That is why the need for prevention and adequate treatment of influenza in this cohort of patients is obvious. The proposed clinical guidelines are aimed at dividing patients into risk groups for influenza virus infection, to offer approaches to diagnosis and treatment. taking IP drugs and other additional characteristics.